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KMID : 0363620100310030098
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Journal of Korean Oriental Medicine
2010 Volume.31 No. 3 p.98 ~ p.106
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Antioxidant and Hepatoprotective Effects of Amomum Xanthoides
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Wang Jing-Hua
Shin Jang-Woo
Son Chang-Gue
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Abstract
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Objective: To examine the in vitro antioxidant and hepatoprotective properties of Amomum xanthoides extract and its fractions.
Methods: Methanol extract of Amomum xanthoides was fractionated into three fractions; petroleum ether fraction (PFAX), water fraction (WFAX) and ethyl acetate fraction (AFAX). The antioxidant and hepatoprotective effects of these fractions were compared by in vitro experiments.
Results: The total phenols content and DPPH (1 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity was found significant in AFAX when compared with other fractions (PFAX, WFAX). AFAX significantly inhibited NO production by RAW 264.7 cells in LPS-activated condition. In Hep cells, AFAX markedly prevented the leakage of LDH and release of AST against CCl4 challenge.
Conclusion: Amomum xanthoides and especially ethyl acetate fraction have potent antioxidative and hepatoprotective properties.
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KEYWORD
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herb, Amomum xanthoides, phenol, antioxidant, hepatoprotective
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